Discovery through Partnership | Excellence through Quality
| Product Name | GF109203X |
| Description |
PKC kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 133052-90-1 |
| Molecular Formula | C25H24N4O2 |
| Molecular Weight | 412.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well) |
| Source | Synthetic |
| Appearance | Red solid |
| SMILES | C4=C(C3=C(C1=C[NH]C2=CC=CC=C12)C(=O)NC3=O)C5=C([N]4CCCN(C)C)C=CC=C5 |
| InChI | InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| InChIKey | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 4), H302 Carcinogenicity (Category 2), H351 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H351 Suspected of causing cancer. Precautionary statements: P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P281 Use personal protective equipment as required. P301 + P312 IF SWALLOWED: C all a POISON CENTER or doctor/ physician if you feel unwell. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | GF109203X (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-447) |
Biological Description
| Alternative Names | 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide, 3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide, 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione, Bisindolylmaleimide I |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 2396 |
| Scientific Background | GF109203X is a very potent inhibitor of protein kinase C; it is selective for the α and β1 isoforms; this could lead to an increase in autophagy. GF109203X is also an inhibitor of glycogen synthase kinase-3 (GSK-3) and has anti-inflammatory effects. It has also been seen to inhibit telomerase activity and necrosis. |
| References |
1. Toullec D., et al. (1991) J. Biol. Chem. 266(24): 15771–15781. 2. Jacobson P.B., et al. (1995) J. Pharma. Exp. Ther. 275(2): 995–1002. 3. Jiang Q., et al. (2011) Mol. Biol. Cell. 22(8): 1167–1180. 4. Kuchera S., et al. (1993) Agents and Actions. 39 Spec No: C169–173. |
Product Images
Chemical structure of GF109203X (SIH-447), a PKC kinase inhibitor. CAS #: 133052-90-1. Molecular Formula: C25H24N4O2. Molecular Weight: 412.5 g/mol.
Powered by Bioz
StressMarq Biosciences :
Based on validation through cited publications.