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| Product Name | Amiodarone Hydrochloride |
| Description |
Autophagy inducer |
| Purity | >99% |
| CAS No. | 19774-82-4 |
| Molecular Formula | C25H29I2NO3•HCl |
| Molecular Weight | 681.77 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 50 mM in DMSO |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | [H+].C1=CC=CC2=C1C(=C(O2)CCCC)C(=O)C3=CC(=C(OCCN(CC)CC)C(=C3)I)I.[Cl-] |
| InChI | InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H |
| InChIKey | ITPDYQOUSLNIHG-UHFFFAOYSA-N |
| Safety Phrases |
Classification: D1B- Toxic Material Causing Immediate and Serious, Toxic Effects, Toxic by inhalation. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H303- May be harmful if swallowed. H312 + H332- Harmful in contact with skin or if inhaled Precautionary statements: P280- Wear protective gloves/ protective clothing. |
| Cite This Product | Amiodarone Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-393) |
Biological Description
| Alternative Names | 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 441325 |
| Scientific Background | Amiodarone is a non-selective ion channel blocker. It has been found, when used in Saccharomyces cerevisiae, to induce an influx of Ca2+ followed by mitochondrial fragmentation and subsequent cell death. Amiodarone has also been shown to induce autophagy by inhibiting mTORC1. Lastly, Amiodarone has broad-spectrum fungicidal activity. |
| References |
1. Zhang Y., et al. (2007). J Biol Chem. 282(52): 37844-53. 2. Balgi A., et al. (2009). PLoS One. 4(9): e7124. |
Product Images
Chemical structure of Amiodarone Hydrochloride (SIH-393), a Autophagy inducer. CAS #: 19774-82-4. Molecular Formula: C25H29I2NO3.HCl. Molecular Weight: 681.77 g/mol.
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