Docetaxel

Microtubule stabilizer

Catalog No. SIH-240

0 out of 5 based on 0 customer ratings
CAS No. 114977-28-5
Molecular Formula C43H53NO14
SKU: SIH-240 Categories: ,

Clear
SIH-240_Docetaxel_Chemical_Structure.png
Product Name Docetaxel
Description

Microtubule stabilizer

Purity >98%
CAS No. 114977-28-5
Molecular Formula C43H53NO14
Molecular Weight 807.88
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 100 mM in DMSO, and to 100 mM in ethanol
Source Synthetic
Appearance White solid
SMILES CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)
InChIKey ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Docetaxel (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-240)

Biological Description

Alternative Names (2α,5β,7β,10β,13α)-4-Acetoxy-1,7,10-trihydroxy-13-{[(2R,3S)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Research Areas Apoptosis, Cancer
PubChem ID 148124
Scientific Background Docetaxel is a semi-synthetic analogue of paclitaxel differing at two positions in its chemical structure (1). It also binds and stabilizes microtubules which leads to cell cycle arrest and apoptosis (2).
References 1. Clarke S.J., and Rivory L.P. (1999) Clin Pharmacokinet. 36(2): 99-114.
2. Woodward E.J. and Twelves C. (2010) Curr. Clin Pharmacol. 5(3): 226-231.

Product Images

<p>Chemical structure of Docetaxel (SIH-240), a Microtubule stabilizing agent. CAS #: 114977-28-5. Molecular Formula: C43H53NO14. Molecular Weight: 807.88 g/mol.</p>

Chemical structure of Docetaxel (SIH-240), a Microtubule stabilizing agent. CAS #: 114977-28-5. Molecular Formula: C43H53NO14. Molecular Weight: 807.88 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “Docetaxel”

Your email address will not be published. Required fields are marked *