Doxorubicin Hydrochloride

Apoptosis inducer

Catalog No. SIH-390

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CAS No. 25316-40-9
Molecular Formula C27H29NO11•HCl
SKU: SIH-390 Categories: ,

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SIH-390_Doxorubicin_Hydrochloride_Chemical_Structure.png
Product Name Doxorubicin Hydrochloride
Description

Apoptosis inducer

Purity >98% (TLC); NMR (Conforms)
CAS No. 25316-40-9
Molecular Formula C27H29NO11•HCl
Molecular Weight 580
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility May be dissolved in water (25 mg/ml); or DMSO (30 mg/ml).
Source Synthetic
Appearance Red- Orange Powder
SMILES [C@H]2(OC1OC(C(O)C(N)C1)C)C[C@@](O)(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)C(=O)CO.[H+].[Cl-]
InChI InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3
InChIKey MWWSFMDVAYGXBV-RUELKSSGSA-N
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H350- May cause cancer.
Precautionary statements:
P201- Obtain special instructions before use.
P308 + P313- IF exposed or concerned: Get medical advice/ attention.
Cite This Product Doxorubicin Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-390)

Biological Description

Alternative Names Adriamycin
Research Areas Alzheimer's Disease, Apoptosis, Cancer, Cell Signaling, DNA Synthesis, DNA/RNA, Epigenetics and Nuclear Signaling, Neurodegeneration, Neuroscience, Topoisomerases
PubChem ID 443939
Scientific Background Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefore induces apoptosis by hindering cellular functions like replication and transcription by specifically inhibiting the binding of reverse transcriptase, RNA polymerase and topoisomerase II. Doxorubicin has some adverse effects for patients including immunosuppressive effects caused by hematologic toxicity. Doxorubicin has also been shown to induce autophagy in a species-specific manner.
References 1. Kusayanagi, T. et al. (2012). Bioorg Med Chem. 20(21): 6248-55.
2. Chen, N. T. et al. (2012). PLoS One. 7(9).
3. Patel, S. et al. (1997). Mol Pharmacol. 52(4): 658-66.
4. Cutts, S. et al. (1996). J Biol Chem. 271(10): 5422-9.
5. Danesi, R. et al. (2004). Transplant Proc. 36(3): 703-4.
6. Dirks-Naylor, A. (2013). Life Sci. 93(24): 913-6.

Product Images

<p>Chemical structure of Doxorubicin Hydrochloride (SIH-390), a Autophagy inducer. CAS #: 25316-40-9. Molecular Formula: C27H29NO11 . HCl. Molecular Weight: 580 g/mol.</p>

Chemical structure of Doxorubicin Hydrochloride (SIH-390), a Autophagy inducer. CAS #: 25316-40-9. Molecular Formula: C27H29NO11 . HCl. Molecular Weight: 580 g/mol.

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