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| Product Name | Epothilone B |
| Description |
Microtubule stabilizer |
| Purity | >98% |
| CAS No. | 152044-54-7 |
| Molecular Formula | C27H41NO6S |
| Molecular Weight | 507.68 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 10 mM in DMSO |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C |
| InChI | InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15) |
| InChIKey | QXRSDHAAWVKZLJ-PVYNADRNSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Epothilone B (StressMarq Biosciences, Canada, Cat # SIH-238) |
Biological Description
| Alternative Names | (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)-1-propen-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione, Patupilone |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 448013 |
| Scientific Background | Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin (1). Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site (2). Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis (3). |
| References |
1. Rosenberg S., Devita V.T., Hellman S. (2005) Cancer: Principles & Practice of Oncology: Lippincott Williams and Wilkins. 2. Julien B., Shah S. (2002) Antimicrob Agents Chemother. 46(9): 2772. 3. Balog D.M., et al. (1996) Angew Chem. 108: 2976. |
Product Images
Chemical structure of Epothilone B (SIH-238), a Microtubule stabilizing agent. CAS #: 152044-54-7. Molecular Formula: C27H41NO6S. Molecular Weight: 507.68 g/mol.
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