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| Product Name | Etoposide |
| Description |
Topoisomerase II inhibitor |
| Purity | >98% |
| CAS No. | 33419-42-0 |
| Molecular Formula | C29H32O13 |
| Molecular Weight | 588.56 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O |
| InChI | InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)1 |
| InChIKey | VJJPUSNTGOMMGY-MRAJQDPKSA-N |
| Safety Phrases |
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S53 - Avoid exposure - obtain special instruction before use Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R45 - May cause cancer R62 - Possible risk of impaired fertility R68 - Possible risk of irreversible effects Hazard Phrases: H302-H350 Precautionary Phrases: P201-P308 + P313 |
| Cite This Product | Etoposide (StressMarq Biosciences, Canada, Cat # SIH-244) |
Biological Description
| Alternative Names | (5S,5aR,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-β-D-glucopyranoside |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 36462 |
| Scientific Background | Etoposide inhibits the enzyme topoisomerase II, which unwinds DNA, and be doing so causes the DNA strand to break. Cancer cells are then less likely to be able to repair this damage (1). |
| References | 1. Gordaliza M., et al. (2004) Toxicon. 44(4): 441-459. |
Product Images
Chemical structure of Etoposide (SIH-244), a Topoisomerase II inhibitor. CAS #: 33419-42-0. Molecular Formula: C29H32O13. Molecular Weight: 588.56 g/mol.
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