ISX9

Induces neuronal differentiation

Catalog No. SIH-628

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CAS No. 832115-62-5
Molecular Formula C11H10N2O2S
SKU: SIH-628 Categories: ,

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SIH-628-ISX9-Chemical-Structure.png
Product Name ISX9
Description

Induces neuronal differentiation

Purity >99% (TLC); NMR (Conforms)
CAS No. 832115-62-5
Molecular Formula C11H10N2O2S
Molecular Weight 234.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility May be dissolved in DMSO (60 mg/ml): or ethanol (16 mg/ml, warm)
Source Synthetic
Appearance Tan powder
SMILES C1CC1NC(=O)C2=NOC(=C2)C3=CC=CS3
InChI 1S/C11H10N2O2S/c14-11(12-7-3-4-7)8-6-9(15-13-8)10-2-1-5-16-10/h1-2,5-7H,3-4H2,(H,12,14)
InChIKey SYENTKHGMVKGAQ-UHFFFAOYSA-N
Safety Phrases Classification: Warning
Cite This Product ISX9 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-628)

Biological Description

Alternative Names N-Cyclopropyl-5-(2-thienyl)-3-isoxa​zolecarboxamide; ISX; Isoxazole-9
Research Areas Calcium Signaling, Neuroscience, Neurotransmission, Stem Cells, Calmodulin, CamK
PubChem ID 19582717
Scientific Background Promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory (1). Induces robust neuronal differentiation in adult neural stem cells (2). Increases insulin production by pancreatic βcells (3). Blocks malignant astrocyte proliferation, downregulates their astrocyte character, induces reentry into the cell cycle and upregulates neuronal gene expression (4). Induces sensory neurons from neuroepithelial stem cells (5). Potentiates cell proliferation and neuronal commitment in the rat dentate gyrus (6).
References 1. D Petrick et al. FASEB J. 2012 26:3148
2. JW Schneider et al. Nat. Chem. Biol. 2008 4:408
3. EM Dioum et al. Proc. Natl. Acad. Sci. U.S.A. 2011 108:20713
4. L Zhang et al. Differentiation 2011 81:233
5. RQ Ali et al. Am. J. Stem Cells 2016 5:19
6. LE Bettio et al. Neuroscience 2016 332:212

Product Images

<p>Chemical structure of ISX9 (SIH-628), a Induces neuronal differentiation. CAS #: 832115-62-5. Molecular Formula: C11H10N2O2S. Molecular Weight: 234.3 g/mol.</p>

Chemical structure of ISX9 (SIH-628), a Induces neuronal differentiation. CAS #: 832115-62-5. Molecular Formula: C11H10N2O2S. Molecular Weight: 234.3 g/mol.

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