Urolithin A

Mitophagy inducer

Catalog No. SIH-610

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CAS No. 1143-70-0
Molecular Formula C13H8O4
SKU: SIH-610 Categories: ,

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SIH-610-Urolithin-A-Chemical-Structure.png
Product Name Urolithin A
Description

Mitophagy inducer

Purity >98% (HPLC); NMR (conforms)
CAS No. 1143-70-0
Molecular Formula C13H8O4
Molecular Weight 228.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility May be dissolved in DMSO (50 mg/ml)
Source Synthetic
Appearance Pale-yellow powder
SMILES OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1
InChI InChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
InChIKey RIUPLDUFZCXCHM-UHFFFAOYSA-N
Safety Phrases Classification: Irritant GHS07
Hazard Statements,
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
Precautionary Statement Codes,
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364
Cite This Product Urolithin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-610)

Biological Description

Alternative Names 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; or 2',7-Dihydroxy-3,4-benzocoumarin
Research Areas Alzheimer's Disease, Cancer, Neurodegeneration, Neuroscience, Parkinson's Disease
PubChem ID 5488186
Scientific Background Urolithin A (UA) is a microbial metabolite of dietary ellagitannins produced in the gut (1). It has been shown to induce mitophagy and prolong lifespan in C. elegans and increase muscle function in rodents (2). It promotes mitophagy and suppresses NLRP3 inflammasome activation in LPS-induced BV2 microglial cells and in an MPTP-induced Parkinson’s disease model (3). The pro-mitophagy activity of Urolitin A may be beneficial in Alzheimer’s disease (4). Ex vivo UA-treated T cells display improved anti-tumor function (5).
References 1.Gonzalez-Barrio R., et al. (2011) J. Agric. Food. Chem. 59:1152
2.Ryu D., et al. 2016 Nat. Med. 22:879
3.Qiu J., et al. 2022 Neuropharmacology 207:108963
4.Jayatunga D.P.W., et al. 2021 Nutrients. 13:3744
5.Denk D., et al. 2022 Immunity. 55:2059

Product Images

<p>Chemical structure of Urolithin A (SIH-610), a Mitophagy inducer. CAS #: 1143-70-0. Molecular Formula: C13H8O4 . Molecular Weight: 228.2 g/mol.</p>

Chemical structure of Urolithin A (SIH-610), a Mitophagy inducer. CAS #: 1143-70-0. Molecular Formula: C13H8O4 . Molecular Weight: 228.2 g/mol.

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