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| Product Name | 17-GMB-APA-GA |
| Description |
Hsp90 inhibitor |
| Purity | >98% |
| Molecular Formula | C39H53N5O11 |
| Molecular Weight | 767.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml) |
| Source | Synthetic |
| Appearance | Purple Solid |
| SMILES | O=C/1C2=C(/C(=O)C=C1NC(=O)C(=CC=C[C@H](OC)[C@@H](OC(=O)N)C(=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2)/C)C)NCCCNC(=O)CCCN3C(=O)C=C/C3=O |
| InChI | InChI=1S/C39H53N5O11/c1-22-18-26-34(42-16-9-15-41-31(46)12-8-17-44-32(47)13-14-33(44)48)28(45)21-27(36(26)50)43-38(51)23(2)10-7-11-29(53-5)37(55-39(40)52)25(4)20-24(3)35(49)30(19-22)54-6/h7,10-11,13- |
| InChIKey | OPWAYYOLUIAKCJ-DAJJPBRBSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | 17-GMB-APA-GA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-115) |
Biological Description
| Alternative Names | [(3R,5S,6R,7S,10S,11S)-21-[3-[4-(2,5-dioxopyrrol-1-yl)butanoylamino]propylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate |
| Research Areas | Cancer, Heat Shock |
| PubChem ID | 57370016 |
| Scientific Background | An analog of geldanamycin containing a maleimido moiety suitable for preparation of geldanamycin immunoconjugates (1-3). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca. |
| References |
1. Mandler R., et al. (2004) Cancer Res. 64: 1460. 2. Mandler R., et al. (2002) Bioconj. Chem. 13: 786. 3. Mandler R., et al. (2000) J. Natl. Cancer Inst. 92: 1573. |
Product Images
Chemical structure of 17-GMB-APA-GA (SIH-115), a Hsp90 inhibitor. CAS #: N/A. Molecular Formula: C39H53N5O11. Molecular Weight: 767.9 g/mol.
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