Product Name | A-967079 |
Description |
TRPA1 blocker |
Purity | >98% |
CAS No. | 1170613-55-4 |
Molecular Formula | C12H14FNO |
Molecular Weight | 207.3 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Inhibitor |
Solubility | Soluble in DMSO (25 mg/ml) |
Source | Synthetic |
Appearance | White solid |
SMILES | CC/C(=NO)/C(=C/C1=CC=C(C=C1)F)/C |
InChI | InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+ |
InChIKey | HKROEBDHHKMNBZ-CHBKHGQFSA-N |
Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302-H315-H317-H318-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338 |
Cite This Product | A-967079 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-301) |
Alternative Names | (1E,3E)-1-(4-Fluorophenyl)-N-hydroxy-2-methyl-1-penten-3-imine |
Research Areas | Ion Channels, Neuroscience |
PubChem ID | 42641861 |
Scientific Background | A-967079 is a TRPA1 antagonist (1) and cell permeable. It has been found to be a potent blocker of TRPA1 channels. It is an oxime analogue and resembles AP18 from a structural perspective, although it has a methyl addition and a chlorine–fluorine substitution. However, compared with AP18 and HC-030031, A-967079 is significantly more potent (100-fold on human and 24-fold on rat TRPA1) and has a much improved pharmacokinetic profile. A-967079 is also more selective, with >1000-fold selectivity over other TRP channels and >150-fold selectivity over 75 other tested proteins (2). |
References | 1. McGaraughty S., et al. (2010) Mol Pain. 6: 14. 2. Chen et al. (2011) PAIN. 152: 1165–1172. |
StressMarq Biosciences :
Based on validation through cited publications.