A-967079

TRPA1 blocker

Catalog No. SIH-301

5 out of 5 based on 1 customer rating
CAS No. 1170613-55-4
Molecular Formula C12H14FNO
SKU: SIH-301 Categories: ,

Clear
SIH-301_A-967079_Chemical_Structure.png
Product Name A-967079
Description

TRPA1 blocker

Purity >98%
CAS No. 1170613-55-4
Molecular Formula C12H14FNO
Molecular Weight 207.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (25 mg/ml)
Source Synthetic
Appearance White solid
SMILES CC/C(=NO)/C(=C/C1=CC=C(C=C1)F)/C
InChI InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+
InChIKey HKROEBDHHKMNBZ-CHBKHGQFSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302-H315-H317-H318-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
Cite This Product A-967079 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-301)

Biological Description

Alternative Names (1E,3E)-1-(4-Fluorophenyl)-N-hydroxy-2-methyl-1-penten-3-imine
Research Areas Ion Channels, Neuroscience
PubChem ID 42641861
Scientific Background A-967079 is a TRPA1 antagonist (1) and cell permeable. It has been found to be a potent blocker of TRPA1 channels. It is an oxime analogue and resembles AP18 from a structural perspective, although it has a methyl addition and a chlorine–fluorine substitution. However, compared with AP18 and HC-030031, A-967079 is significantly more potent (100-fold on human and 24-fold on rat TRPA1) and has a much improved pharmacokinetic profile. A-967079 is also more selective, with >1000-fold selectivity over other TRP channels and >150-fold selectivity over 75 other tested proteins (2).
References 1. McGaraughty S., et al. (2010) Mol Pain. 6: 14. 2. Chen et al. (2011) PAIN. 152: 1165–1172.

Product Images

<p>Chemical structure of A-967079 (SIH-301), a TRPA1 blocker. CAS #: 1170613-55-4. Molecular Formula: C12H14FNO. Molecular Weight: 207.3 g/mol.</p>

Chemical structure of A-967079 (SIH-301), a TRPA1 blocker. CAS #: 1170613-55-4. Molecular Formula: C12H14FNO. Molecular Weight: 207.3 g/mol.

Reviews

1 review for A-967079

  1. 5 out of 5

    :

    Based on validation through cited publications.

Add a review

Your email address will not be published. Required fields are marked *