AG 1478

Name: AG 1478
SKU: SIH-425
Availability: InStock

EGFR kinase inhibitor

Catalog No. SIH-425

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CAS No.	153436-53-4
Molecular Formula	C16H14ClN3O2

SKU: SIH-425 Categories: Inhibitor, Small Molecules

Product Name	AG 1478
Description	EGFR kinase inhibitor
Purity	>98% (HPLC)
CAS No.	153436-53-4
Molecular Formula	C₁₆H₁₄ClN₃O₂
Molecular Weight	315.8
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (10 mg/ml)
Source	Synthetic
Appearance	White to light yellow solid
SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC
InChI	InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
InChIKey	GFNNBHLJANVSQV-UHFFFAOYSA-N
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product	AG 1478 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-425)

Alternative Names	N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine, 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	2051
Scientific Background	AG 1478 is a potent and selective inhibitor of EGFR. It does so by reducing EGF-stimulated DNA synthesis (seen in rat fibroblasts) and blocking EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction (seen in A431 cells). AG 1478 is cell-permeable and active in vivo.
References	1. Osherov N., & Levitzki A. (1994) Euro J. Biochem. 225(3): 1047–1053. 2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546. 3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242.

Chemical structure of AG 1478 (SIH-425), a EGFR kinase inhibitor. CAS #: 175178-82-2. Molecular Formula: C16H14ClN3O2. Molecular Weight: 315.8 g/mol.

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