Amlodipine

L-type Ca channel blocker

Catalog No. SIH-315

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CAS No. 111470-99-6
Molecular Formula C20H25ClN2O5•C6H5SO3H
SKU: SIH-315 Categories: ,

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SIH-315_Amlodipine_Chemical_Structure.png
Product Name Amlodipine
Description

L-type Ca channel blocker

Purity >98%
CAS No. 111470-99-6
Molecular Formula C20H25ClN2O5•C6H5SO3H
Molecular Weight 567.05
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO and to 10 mM in water
Source Synthetic
Appearance White Solid
SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
InChI InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11
InChIKey HTIQEAQVCYTUBX-UHFFFAOYSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R22 - Harmful if swallowed
R62 - Possible risk of impaired fertility
Hazard Phrases:
H302-H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
Cite This Product Amlodipine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-315)

Biological Description

Alternative Names 3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate, Norvasc
Research Areas Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels
PubChem ID 2162
Scientific Background Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure.
References 1. Luksa J., Josic D., Kremser M., Kopitar Z and Milutinovic S. (1997) J Chromatorgraphy. B, Biomed Sci and App. 693(2): 367-375.
2. Bahl V.K., Jadhav U.M., Thacker H.P. (2009) Am J Cardiovasc Drugs. 9(3): 135-142.

Product Images

<p>Chemical structure of Amlodipine (SIH-315), a L-type Ca channel blocker. CAS #: 111470-99-6. Molecular Formula: C20H25ClN2O5 · C6H5SO3H . Molecular Weight: 567.05 g/mol.</p>

Chemical structure of Amlodipine (SIH-315), a L-type Ca channel blocker. CAS #: 111470-99-6. Molecular Formula: C20H25ClN2O5 · C6H5SO3H . Molecular Weight: 567.05 g/mol.

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