Aphidicolin

DNA polymerase inhibitor

Catalog No. SIH-605

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CAS No. 38966-21-1
Molecular Formula C20H34O4
SKU: SIH-605 Categories: ,

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SIH-605-Aphidicolin-Chemical-Structure.png
Product Name Aphidicolin
Description

DNA polymerase inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 38966-21-1
Molecular Formula C20H34O4
Molecular Weight 338.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (10 mg/ml); or ethanol (1 mg/ml)
Source Synthetic
Appearance White powder
SMILES C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
InChI InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChIKey NOFOAYPPHIUXJR-APNQCZIXSA-N
Safety Phrases Classification: Caution: Not a hazardous substance or mixture.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Aphidicolin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-605)

Biological Description

Alternative Names (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol; (from Nigrospora sp.)
Research Areas Cell Signaling, Epigenetics and Nuclear Signaling, Neuroscience
PubChem ID 457964
Scientific Background Aphidicolin specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases (1). Arrests cell cycle at early S phase while allowing continued cell growth(2). Potentiates apoptosis induction induced by other agents(3). Increases gene amplification frequency in HeLa S3 cells overexpressing Bcl-2(4).
References 1.,Syvaoja J., et al. (1990) Proc. Natl. Acad. Sci. USA. 87(17):6664-6668.
2.,Urbani L., et al. (1995) Exp. Cell Res. 219(1):159-168.
3.,Kuwakado K., et al. (1993) Biochem. Pharmacol. 46:1909-1916.
4.,Yin D.X., and Schimke R.T. (1996) Proc. Natl. Acad. Sci. USA. 93:3394-3398.

Product Images

<p>Chemical structure of Aphidicolin (SIH-605), a DNA polymerase inhibitor. CAS #: 38966-21-1. Molecular Formula: C20H34O4. Molecular Weight: 338.5 g/mol.</p>

Chemical structure of Aphidicolin (SIH-605), a DNA polymerase inhibitor. CAS #: 38966-21-1. Molecular Formula: C20H34O4. Molecular Weight: 338.5 g/mol.

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