Astemizole

Herg channel blocker

Catalog No. SIH-302

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CAS No. 68844-77-9
Molecular Formula C28H31FN4O
SKU: SIH-302 Categories: ,

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SIH-302_Astemizole_Chemical_Structure.png
Product Name Astemizole
Description

Herg channel blocker

Purity >98%
CAS No. 68844-77-9
Molecular Formula C28H31FN4O
Molecular Weight 458.57
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO and to 25 mM in ethanol
Source Synthetic
Appearance White solid
SMILES COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
InChI InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-2
InChIKey GXDALQBWZGODGZ-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62 - Possible risk of impaired fertility
Hazard Phrases:
H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
Cite This Product Astemizole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-302)

Biological Description

Alternative Names 1-(4-Fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine, Hismanal
Research Areas Ion Channels, Neuroscience
PubChem ID 2247
Scientific Background Astemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, and the binding is primarily in the peripheral nervous system (1). It is metabolized by CYP3A4 (2).
References 1. Laduron P.M., Janssen P.F., Commeren W. and Leysen J.E. (1982) Mol Pharmacol. 21(2): 294-300.
2. Maysumoto S., Yamazoe Y. (2001) Br. J Clin Pharamcol. 51(2): 133-142.

Product Images

<p>Chemical structure of Astemizole (SIH-302), a Herg channel blocker. CAS #: 68844-77-9. Molecular Formula: C28H31FN4O. Molecular Weight: 458.57 g/mol.</p>

Chemical structure of Astemizole (SIH-302), a Herg channel blocker. CAS #: 68844-77-9. Molecular Formula: C28H31FN4O. Molecular Weight: 458.57 g/mol.

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