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| Product Name | Auranofin |
| Description |
IKK kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 34031-32-8 |
| Molecular Formula | C20H34AuO9PS |
| Molecular Weight | 678.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (5 mg/ml) or 100% ethanol (4 mg/ml) |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CCP(=[Au]S[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COC(=O)C)OC(=O)C)OC(=O)C)OC(=O)C)(CC)CC |
| InChI | InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1 |
| InChIKey | AUJRCFUBUPVWSZ-UHFFFAOYSA-M |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 3), H301 Reproductive toxicity (Category 2), H361 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H361 Suspected of damaging fertility or the unborn child. Precautionary statements: P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P281 Use personal protective equipment as required. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Auranofin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-493) |
Biological Description
| Alternative Names | 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate, 3,4,5-Triacetyloxy-6-(acetyloxymethyl) oxane-2-thiolate triethylphosphanium, SKF 39162 |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 24199313 |
| Scientific Background | Auranofin is derivative of gold and has been widely used as an anti-arthritic drug. It inhibits both leukocyte activation pathways at multiple sites and the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin has been shown to inhibit human neutrophil 5-lipoxygenase, thioredoxin reductase (TrxR), IκB kinase (IKK). |
| References |
1. Betts W.H., Hurst N.P., Murphy G.A., & Cleland L.G. (1990) Biochem. Pharm. 39(7). 1233–1237. 2. Rudkowski R., Ziegler J.B., Graham G.G., & Champion G.D. (1991) Biochem. Pharm. 41(12): 1921–1929. |
Product Images
Chemical structure of Auranofin (SIH-493), a IKK kinase inhibitor. CAS #: 34031-32-8. Molecular Formula: C20H34AuO9PS. Molecular Weight: 678.5 g/mol.
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