Bafilomycin A1

Autophagy inhibitor

Catalog No. SIH-391

5 out of 5 based on 2 customer ratings
CAS No. 88899-55-2
Molecular Formula C35H58O9
SKU: SIH-391 Categories: ,

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SIH-391_Bafilomycin_A1_Chemical_Structure.png
Product Name Bafilomycin A1
Description

Autophagy inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 88899-55-2
Molecular Formula C35H58O9
Molecular Weight 622.84
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (50mg/mL)
Source Synthetic
Appearance White powder to colorless film.
SMILES [C@]1(O[C@@H]([C@H]([C@H](O)C1)C)C(C)C)(O)[C@H]([C@H](O)[C@@H]([C@H]2OC(=O)C(=C/C(=C/[C@H]([C@@H](O)[C@H](CC(=C/C=C/[C@@H]2OC)
InChI InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H
InChIKey XDHNQDDQEHDUTM-JQWOJBOSSA-N
Safety Phrases Classification: D2B- Toxic Material Causing Other Toxic Effects Irritant
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315- Causes skin irritation.
H319- Causes serious eye irritation.
H335- May cause respiratory irritation.
Precautionary statements:
P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264- Wash skin thoroughly after handling.
P271- Use only outdoors or in a well-ventilated area.
P280- Wear protective gloves/ eye protection/ face protection.
P302 + P352- IF ON SKIN: Wash with plenty of soap and water.
P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312- Call a POISON CENTER or doctor/ physician if you feel unwell.
P321- Specific treatment (see supplemental first aid instructions on this label).
P332 + P313- If skin irritation occurs: Get medical advice/ attention.
P337 + P313- If eye irritation persists: Get medical advice/ attention.
P362- Take off contaminated clothing and wash before reuse.
P403 + P233- Store in a well-ventilated place. Keep container tightly closed.
P405- Store locked up.
P501- Dispose of contents/ container to an approved waste disposal plant.
Cite This Product Bafilomycin A1 (StressMarq Biosciences, Canada, Cat # SIH-391)

Biological Description

Alternative Names (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
Research Areas Autophagy, Cancer
PubChem ID 6436223
Scientific Background Bafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus. It selectively inhibits vacuolar-type H+-ATPases, allowing it to be used to differentiate between different types of ATPases. Bafilomycin also acts to inhibit autophagy by either blocking autophagosome-lysosome fusion, or by blocking lysosomal degradation.
References 1. Gagliardi S., et al. (1999). Curr Med Chem. 6(12): 1197-212.
2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16.
3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42.

Product Images

<p>Chemical structure of Bafilomycin A1 (SIH-391), a Autophagy inhibitor. CAS #: 88899-55-2. Molecular Formula: C35H58O9. Molecular Weight: 622.84 g/mol.</p>

Chemical structure of Bafilomycin A1 (SIH-391), a Autophagy inhibitor. CAS #: 88899-55-2. Molecular Formula: C35H58O9. Molecular Weight: 622.84 g/mol.

Reviews

2 reviews for Bafilomycin A1

  1. 5 out of 5

    :

    Based on validation through cited publications.

  2. 5 out of 5

    :

    We ordered this inhibitor and utilized 100 nm to pre-treat differentiated THP-1 cells for 1 h before incubating with autophagy inducer. We showed that this inhibitor can efficiently inhibit the autophagy flux by measuring the level of LC3-II. We recommend it.

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