Beta-Lapachone

DNA topoisomerase I inhibitor

Catalog No. SIH-589

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CAS No. 4707-32-8
Molecular Formula C15H14O3
SKU: SIH-589 Categories: ,

SIH-589-Beta-Lapachone-Chemical-Structure.png
Product Name Beta-Lapachone
Description

DNA topoisomerase I inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 4707-32-8
Molecular Formula C15H14O3
Molecular Weight 242.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (35 mg/ml); or Ethanol (15 mg/ml)
Source Synthetic
Appearance Orange powder
SMILES CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C
InChI InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
InChIKey QZPQTZZNNJUOLS-UHFFFAOYSA-N
Safety Phrases May be harmful by inhalation, ingestion, or skin absorption. May cause eye, skin, or respiratory system irritation.
Cite This Product Beta-Lapachone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-589)

Biological Description

Alternative Names 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione; NSC-26326
Research Areas Cell Signaling, DNA Synthesis, DNA/RNA, Epigenetics and Nuclear Signaling, Topoisomerases
PubChem ID 3885
Scientific Background β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. It induces apoptosis in HL-60 and human prostate cancer cells.
References 1. Planchon S.M., et al. (1995) Cancer Research. 55(17): 3706-3711.

Product Images

<p>Chemical structure of Beta-Lapachone (SIH-589), a DNA topoisomerase I inhibitor. CAS #: 4707-32-8. Molecular Formula: C15H14O3. Molecular Weight: 242.3 g/mol.</p>

Chemical structure of Beta-Lapachone (SIH-589), a DNA topoisomerase I inhibitor. CAS #: 4707-32-8. Molecular Formula: C15H14O3. Molecular Weight: 242.3 g/mol.

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