BRL-50481

PDE7 inhibitor

Catalog No. SIH-374

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CAS No. 433695-36-4
Molecular Formula C9H12N2O4S
SKU: SIH-374 Categories: ,

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SIH-374_BRL-50481_Chemical_Structure.png
Product Name BRL-50481
Description

PDE7 inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 433695-36-4
Molecular Formula C9H12N2O4S
Molecular Weight 244.26
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (40 mg/ml) or Ethanol (5 mg/ml)
Source Synthetic
Appearance Cream solid
SMILES CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)C
InChI InChI=1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3
InChIKey IFIUFCJFLGCQPH-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product BRL-50481 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-374)

Biological Description

Alternative Names N,N,2-Trimethyl-5-nitro-benzenesulfonamide
Research Areas Neuroscience
PubChem ID 2921148
Scientific Background BRL-50481 is a selective phosphodiesterase 7 (PDE7) inhibitor. In the presence of BRL-50481 the activity of hrPDE7A1 was inhibited against the phosphodiesterase (PDE3) and (PDE4) (1). Studies have suggested a potential role of BRL-50481 in the treatment of osteoporosis (2).
References 1. Smith J., et al. (2004) Molecular Biology Pharmacology. 66(6): 1679-89.
2. Pekkinen M., et al. (2008) Bone. 43(1): 84-91.

Product Images

<p>Chemical structure of BRL-50481 (SIH-374), a PDE7 inhibitor. CAS #: 433695-36-4. Molecular Formula: C9H12N2O4S. Molecular Weight: 244.26 g/mol.</p>

Chemical structure of BRL-50481 (SIH-374), a PDE7 inhibitor. CAS #: 433695-36-4. Molecular Formula: C9H12N2O4S. Molecular Weight: 244.26 g/mol.

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