C16

Name: C16
SKU: SIH-498
Availability: InStock

PKR kinase inhibitor

Catalog No. SIH-498

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CAS No.	608512-97-6
Molecular Formula	C13H8N4OS

SKU: SIH-498 Categories: Inhibitor, Small Molecules

Product Name	C16
Description	PKR kinase inhibitor
Purity	>98% (HPLC)
CAS No.	608512-97-6
Molecular Formula	C₁₃H₈N₄OS
Molecular Weight	268.3
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO 12 mg/ml
Source	Synthetic
Appearance	Solid
SMILES	C1=CC2=C(C3=C1NC(=O)/C3=CC4=CNC=N4)SC=N2
InChI	InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3+
InChIKey	VFBGXTUGODTSPK-FPYGCLRLSA-N
Safety Phrases	Classification: Chronic aquatic toxicity (Category 4), H413 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H413 May cause long lasting harmful effects to aquatic life. Precautionary statements: P273 Avoid release to the environment. P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product	C16 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-498)

Alternative Names	Imidazolo-oxindole PKR inhibitor C16, 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	67016828
Scientific Background	C16 is a derivative of imidazolo-oxindole and inhibits RNA-dependent protein kinases (PKR). Its inhibition effect on PKR is ATP-binding site directed. C16 has been shown to specifically inhibit the apoptotic PKR/eIF2a signaling pathway.
References	1. Couturier J., et al. (2010) J. Biol. Chem. 285(2): 1272–1282. 2. Jammi N.V., Whitby L.R., & Beal P.A. (2003) Biochem. Biophys.Res. Comm. 308(1):50–57.

Chemical structure of C16 (SIH-498), a PKR kinase inhibitor. CAS #: 608512-97-6. Molecular Formula: C13H8N4OS. Molecular Weight: 268.3 g/mol.

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