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| Product Name | Camostat mesylate |
| Description |
Serine protease inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 59721-29-8 |
| Molecular Formula | C20H22N4O5·CH3SO3H |
| Molecular Weight | 494.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (50 mg/mL) or Water (50mg/mL) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | O=C(C2=CC=C(NC(N)=N)C=C2)OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1.CS(=O)(O)=O |
| InChI | InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4) |
| InChIKey | FSEKIHNIDBATFG-UHFFFAOYSA-N |
| Safety Phrases | General Classification: Warning Hazard statements: H315-H319-H335-H400 Precautionary statements: P261-P273-P305 + P351 + P338 |
| Cite This Product | Camostat mesylate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-585) |
Biological Description
| Alternative Names | 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate |
| Research Areas | Cancer, Cell Signaling |
| PubChem ID | 5284360 |
| Scientific Background | Camostat mesylate is an orally active protease inhibitor. It inhibits the serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (Covid-19) into lung cells and Human coronavirus NL63 into HeLa cells. It has also been used in some cancer treatments, against viral infections, and for inhibiting fibrosis in liver, kidney disease and pancreatitis. |
| References |
1. Okuno M., et al. (2002). Front Biosci. 7 (4): d204-218. 2. Hsieh H. P., Hsu, J. T. (2007). Current Pharmaceutical Design. 13 (34): 3531–3542. 3. Kitamura K., Tomita K. (2012). Clinical and Experimental Nephrology. 16 (1): 44–48. 4. Kawase M., Shirato K., van der Hoek L., Taguchi F., Matsuyama S. (2012) J Virol. 86(12): 6537-6545. 5.. Hoffman M., et al. (2020) Cell: https://doi.org/10.1016/j.cell.2020.02.052 |
Product Images
Chemical structure of Camostat mesylate (SIH-585), a Serine protease inhibitor. CAS #: 59721-29-8. Molecular Formula: C20H22N4O5·CH3SO3H. Molecular Weight: 494.5 g/mol.
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