Cantharidin

Phosphatase PP2A inhibitor

Catalog No. SIH-519

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CAS No. 56-25-7
Molecular Formula C10H12O4
SKU: SIH-519 Categories: ,

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SIH-519_Cantharidin_Chemical_Structure.png
Product Name Cantharidin
Description

Phosphatase PP2A inhibitor

Purity >98% (GC)
CAS No. 56-25-7
Molecular Formula C10H12O4
Molecular Weight 196.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO or 100% ethanol
Source Synthetic
Appearance White to off-white solid
SMILES C[C@@]12[C@H]3CC[C@@H]([C@@]1(C(=O)OC2=O)C)O3
InChI InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3
InChIKey DHZBEENLJMYSHQ-UHFFFAOYSA-N
Safety Phrases Classification:
Acute toxicity, Oral (Category 2), H300
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H300 Fatal if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ containerto an approved waste disposal plant.
Cite This Product Cantharidin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-519)

Biological Description

Alternative Names 3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione, 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran, Cantharidine, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
Research Areas Cell Signaling
PubChem ID 2545
Scientific Background Cantharidin is an inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). It is a naturally occurring toxin found in Mylabris phalerata.
References 1. Honkanen R. E. (1993) FEBS Letters. 330(3): 283–286.
2. Eldridge R., & Casida J.E. (1995) Toxic. App. Pharm. 130(1): 95–100.

Product Images

<p>Chemical structure of Cantharidin (SIH-519), a Phosphatase PP2A inhibitor. CAS #: 56-25-7. Molecular Formula: C10H12O4. Molecular Weight: 196.2 g/mol.</p>

Chemical structure of Cantharidin (SIH-519), a Phosphatase PP2A inhibitor. CAS #: 56-25-7. Molecular Formula: C10H12O4. Molecular Weight: 196.2 g/mol.

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