Capsaicin

TRPV1opener

Catalog No. SIH-322

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CAS No. 404-86-4
Molecular Formula C18H27NO3
SKU: SIH-322 Categories: ,

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SIH-322_Capsaicin_Chemical_Structure.png
Product Name Capsaicin
Description

TRPV1opener

Purity >60% (HPLC); NMR (conforms)
CAS No. 404-86-4
Molecular Formula C18H27NO3
Molecular Weight 305.41
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Small Molecules
Solubility Soluble in DMSO (20 mg/mL) and ethanol (15 mg/mL)
Source Synthetic
Appearance Off-White Solid
SMILES CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19
InChIKey YKPUWZUDDOIDPM-SOFGYWHQSA-N
Safety Phrases Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with shin and eyes
Risk Phrases:
R25-37/38-41-42/43
Hazard Phrases:
H301-H311-H315-H317-H318-H334-H335
Precautionary Phrases:
P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311
Cite This Product Capsaicin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-322)

Biological Description

Alternative Names (6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide, 8-Methyl-N-vanillyl-trans-6-nonenamide
Research Areas Ion Channels, Neuroscience, Transient Receptor Potential (TRP) Channels
PubChem ID 1548943
Scientific Background Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel (1, 2). It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons (1). Powerful excitant of peripheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets (3).
References 1. Caterina M.J., et al. (1997) Nature. 389(6653): 816-824.
2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333.
3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188.

Product Images

<p>Chemical structure of Capsaicin (SIH-322), a TRPV1opener. CAS #: 404-86-4. Molecular Formula: C18H27NO3. Molecular Weight: 305.41 g/mol.</p>

Chemical structure of Capsaicin (SIH-322), a TRPV1opener. CAS #: 404-86-4. Molecular Formula: C18H27NO3. Molecular Weight: 305.41 g/mol.

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