Product Name | Capsaicin |
Description |
TRPV1opener |
Purity | >60% (HPLC); NMR (conforms) |
CAS No. | 404-86-4 |
Molecular Formula | C18H27NO3 |
Molecular Weight | 305.41 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Small Molecules |
Solubility | Soluble in DMSO (20 mg/mL) and ethanol (15 mg/mL) |
Source | Synthetic |
Appearance | Off-White Solid |
SMILES | CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC |
InChI | InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19 |
InChIKey | YKPUWZUDDOIDPM-SOFGYWHQSA-N |
Safety Phrases |
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with shin and eyes Risk Phrases: R25-37/38-41-42/43 Hazard Phrases: H301-H311-H315-H317-H318-H334-H335 Precautionary Phrases: P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311 |
Cite This Product | Capsaicin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-322) |
Alternative Names | (6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide, 8-Methyl-N-vanillyl-trans-6-nonenamide |
Research Areas | Ion Channels, Neuroscience, Transient Receptor Potential (TRP) Channels |
PubChem ID | 1548943 |
Scientific Background | Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel (1, 2). It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons (1). Powerful excitant of peripheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets (3). |
References |
1. Caterina M.J., et al. (1997) Nature. 389(6653): 816-824. 2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333. 3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188. |
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