CCT196969

RAF Inhibitor

Catalog No. SIH-185

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CAS No. 1163719-56-9
Molecular Formula C27H24FN7O3
SKU: SIH-185 Categories: ,

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SIH-185_CCT196969_Chemical_Structure.png
Product Name CCT196969
Description

RAF Inhibitor

Purity 96%
CAS No. 1163719-56-9
Molecular Formula C27H24FN7O3
Molecular Weight 513.53
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Product Type Inhibitor
Solubility Soluble in DMSO
Source Synthetic
Appearance White Solid
SMILES CC(C)C)C1=NN(C2=CC=CC=C2)C(NC(NC(C(F)=C3)=CC=C3OC4=C5C(NC(C=N5)=O)=NC=C4)=O)=C1
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product CCT196969 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-185)

Biological Description

Alternative Names 1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea, CCT-196969, CCT 196969
Research Areas Apoptosis, Cancer
Scientific Background CCT196969, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant melanoma tumors. It is also active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.1µM and 0.03µM for BRAF kinase and SRC kinase respectively.
References 1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.

Product Images

<p>Chemical structure of CCT196969 (SIH-185), a RAF Inhibitor. CAS #: 1163719-56-9. Molecular Formula: C27H24FN7O3. Molecular Weight: 513.53 g/mol.</p>

Chemical structure of CCT196969 (SIH-185), a RAF Inhibitor. CAS #: 1163719-56-9. Molecular Formula: C27H24FN7O3. Molecular Weight: 513.53 g/mol.

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