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| Product Name | Chloroquine diphosphate |
| Description |
Autophagy inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 50-63-5 |
| Molecular Formula | C18H26ClN3·2H3PO4 |
| Molecular Weight | 515.86 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in water (25mg/mL) |
| Source | Synthetic |
| Appearance | Beige Solid |
| SMILES | C1=CC(=CC2=C1C(=CC=N2)NC(CCCN(CC)CC)C)Cl.O=[P](O)(O)O.O=[P](O)(O)O |
| InChI | InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4) |
| InChIKey | QKICWELGRMTQCR-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Chloroquine diphosphate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-405) |
Biological Description
| Alternative Names | N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 64927 |
| Scientific Background | Chloroquine diphosphate was originally developed as a treatment against malaria. It has since been implicated in cancer research as it inhibits cell growth and induces cell death in a number of cancer cell lines. Chloroquine also inhibits autophagy by specifically blocking acidification of the lysosomes which fuse with autophagosomes. This consequently prevents the degradation of materials. |
| References |
1. Jiang P.D., et al. (2010) Biomed Pharmacother. 64(9): 609-14. 2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81. |
Product Images
Chemical structure of Chloroquine diphosphate (SIH-405), a Autophagy inhibitor. CAS #: 50-63-5. Molecular Formula: C18H26ClN3·2H3PO4. Molecular Weight: 515.86 g/mol.
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Based on validation through cited publications.