Chloroquine diphosphate

Autophagy inhibitor

Catalog No. SIH-405

5 out of 5 based on 1 customer rating
CAS No. 50-63-5
Molecular Formula C18H26ClN3·2H3PO4
SKU: SIH-405 Categories: ,

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SIH-405_Chloroquine_diphosphate_Chemical_Structure.png
Product Name Chloroquine diphosphate
Description

Autophagy inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 50-63-5
Molecular Formula C18H26ClN3·2H3PO4
Molecular Weight 515.86
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in water (25mg/mL)
Source Synthetic
Appearance Beige Solid
SMILES C1=CC(=CC2=C1C(=CC=N2)NC(CCCN(CC)CC)C)Cl.O=[P](O)(O)O.O=[P](O)(O)O
InChI InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChIKey QKICWELGRMTQCR-UHFFFAOYSA-N
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Chloroquine diphosphate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-405)

Biological Description

Alternative Names N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Research Areas Autophagy, Cancer
PubChem ID 64927
Scientific Background Chloroquine diphosphate was originally developed as a treatment against malaria. It has since been implicated in cancer research as it inhibits cell growth and induces cell death in a number of cancer cell lines. Chloroquine also inhibits autophagy by specifically blocking acidification of the lysosomes which fuse with autophagosomes. This consequently prevents the degradation of materials.
References 1. Jiang P.D., et al. (2010) Biomed Pharmacother. 64(9): 609-14.
2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81.

Product Images

<p>Chemical structure of Chloroquine diphosphate (SIH-405), a Autophagy inhibitor. CAS #: 50-63-5. Molecular Formula: C18H26ClN3·2H3PO4. Molecular Weight: 515.86 g/mol.</p>

Chemical structure of Chloroquine diphosphate (SIH-405), a Autophagy inhibitor. CAS #: 50-63-5. Molecular Formula: C18H26ClN3·2H3PO4. Molecular Weight: 515.86 g/mol.

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