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| Product Name | Cyclopamine |
| Description |
Hedgehog signaling blocker |
| Purity | >98% |
| CAS No. | 4449-51-8 |
| Molecular Formula | C27H41NO2 |
| Molecular Weight | 434.15 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 5 mM in ethanol |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1 |
| InChI | InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17 |
| InChIKey | QASFUMOKHFSJGL-LAFRSMQTSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62- Possible risk of impaired fertility |
| Cite This Product | Cyclopamine (StressMarq Biosciences, Canada, Cat # SIH-226) |
Biological Description
| Alternative Names | (3β,22S,23R)-17,23-Epoxyveratraman-3-ol |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Hedgehog Pathway Inhibitors |
| PubChem ID | 442972 |
| Scientific Background | Cyclopamine is a hedgehog signaling pathway inhibitor that influences the balance between the active and inactive forms of the Smoothened protein (1). It is being investigated as a treatment agent in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma (1, 2). |
| References |
1. Beachy P.A., et al. (2000) Nature. 406(6799): 1005-1009. 2. Yauch R.L., et al. (2009) Science. 326(5952): 572-574. |
Product Images
Chemical structure of Cyclopamine (SIH-226), a Inhibits hedgehog signaling. CAS #: 4449-51-8. Molecular Formula: C27H41NO2. Molecular Weight: 434.15 g/mol.
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