Cyclosporine

Immunosuppressant

Catalog No. SIH-201

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CAS No. 59865-13-3
Molecular Formula C62H111N11O12
SKU: SIH-201 Categories: ,

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SIH-201_Cyclosporine_Chemical_Structure.png
Product Name Cyclosporine
Description

Immunosuppressant

Purity >99%
CAS No. 59865-13-3
Molecular Formula C62H111N11O12
Molecular Weight 1202.63
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO, 50 mM in ethanol
Source Synthetic
Appearance White Solid
SMILES CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(
InChI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(
InChIKey PMATZTZNYRCHOR-IMVLJIQESA-N
Safety Phrases Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
R45 - May cause cancer
R62 - Possible risk of impaired fertility
R68 - Possible risk of irreversible effects
Hazard Phrases:
H302-H350-H360
Precautionary Phrases:
P201-P308 + P313
Cite This Product Cyclosporine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-201)

Biological Description

Alternative Names (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, Cyclosporin A
Research Areas Apoptosis, Cancer
PubChem ID 5284373
Scientific Background Cyclosporin A is a hydrophobic cyclic peptide, and is a potent immune-suppressant and antifungal. It acts via its ability to bind to a family of intracellular proteins (1). The immunosuppressant action is mediated by the complex Cyclosporin-A-cyclophilin that specifically inhibits the Ca2+/calmodulin-dependent serine-threonine-protein phosphatase-2B. This is turn inhibits calcineurin and promotes dephosphorylation of transcription factor NF-AT and T-cell activation (2).
References 1. Heitman J., et al. (1992) New Biol. 4:448.
2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.

Product Images

<p>Chemical structure of Cyclosporine (SIH-201), a Inhibits mitochondrial permeability pore opening. CAS #: 59865-13-3. Molecular Formula: C62H111N11O12 . Molecular Weight: 1202.63 g/mol.</p>

Chemical structure of Cyclosporine (SIH-201), a Inhibits mitochondrial permeability pore opening. CAS #: 59865-13-3. Molecular Formula: C62H111N11O12 . Molecular Weight: 1202.63 g/mol.

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