CZC 54252 Hydrochloride

LRRK2 inhibitor

Catalog No. SIH-439

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CAS No. 1191911-27-9, 1330003-04-7
Molecular Formula C22H26Cl2N6O4S
SKU: SIH-439 Categories: ,

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SIH-439_CZC-54252_Hydrochloride_Chemical_Structure.png
Product Name CZC 54252 Hydrochloride
Description

LRRK2 inhibitor

Purity >98%
CAS No. 1191911-27-9, 1330003-04-7
Molecular Formula C22H26Cl2N6O4S
Molecular Weight 541.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance Yellow solid
SMILES COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl
InChI InChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H
InChIKey KWCBHUPLQMUKAF-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product CZC 54252 Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-439)

Biological Description

Alternative Names N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide hydrochloride
Research Areas Cell Signaling, Neurodegeneration, Neuroscience, Multiple System Atrophy
Scientific Background CZC 54252 Hydrochloride is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor.
References 1. Kramer T., Lo Monte F., Göring S., Okala Amombo G.M., & Schmidt B. (2012) ACS Chem. Neuro. 3(3): 151–160.

Product Images

<p>Chemical structure of CZC 54252 Hydrochloride (SIH-439), a LRRK2 inhibitor. CAS #: 1191911-27-9. Molecular Formula: C22H26Cl2N6O4S. Molecular Weight: 541.5 g/mol.</p>

Chemical structure of CZC 54252 Hydrochloride (SIH-439), a LRRK2 inhibitor. CAS #: 1191911-27-9. Molecular Formula: C22H26Cl2N6O4S. Molecular Weight: 541.5 g/mol.

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