Product Name | DAPT |
Description |
γ-secretase inhibitor |
Purity | >99% |
CAS No. | 208255-80-5 |
Molecular Formula | C23H26F2N2O4 |
Molecular Weight | 432.46 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Inhibitor |
Solubility | Soluble to 100 mM in DMSO |
Source | Synthetic |
Appearance | White to off-white powder |
SMILES | [C@H](NC(=O)[C@@H](NC(=O)CC1=CC(=CC(=C1)F)F)C)(C2=CC=CC=C2)C(OC(C)(C)C)=O |
InChI | InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1 |
InChIKey | DWJXYEABWRJFSP-XOBRGWDASA-N |
Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
Cite This Product | DAPT (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-378) |
Alternative Names | N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester |
Research Areas | Cell Signaling, Neuroscience |
PubChem ID | 5311272 |
Scientific Background | Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation. |
References |
1. Dovey H.F., et al. (2001) J. Neurochem. 76(1): 173-81. 2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506. 3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48. |
Reviews
There are no reviews yet.