DAPT

γ-secretase inhibitor

Catalog No. SIH-378

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CAS No. 208255-80-5
Molecular Formula C23H26F2N2O4
SKU: SIH-378 Categories: ,

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SIH-378_DAPT_Chemical_Structure.png
Product Name DAPT
Description

γ-secretase inhibitor

Purity >99%
CAS No. 208255-80-5
Molecular Formula C23H26F2N2O4
Molecular Weight 432.46
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance White to off-white powder
SMILES [C@H](NC(=O)[C@@H](NC(=O)CC1=CC(=CC(=C1)F)F)C)(C2=CC=CC=C2)C(OC(C)(C)C)=O
InChI InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChIKey DWJXYEABWRJFSP-XOBRGWDASA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product DAPT (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-378)

Biological Description

Alternative Names N-[(3,5-Difluorophenyl)acetyl]-L-al­anyl-2-phenyl]glycine-1,1-dimethylethyl ester
Research Areas Cell Signaling, Neuroscience
PubChem ID 5311272
Scientific Background Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.
References 1. Dovey H.F., et al. (2001) J. Neurochem. 76(1): 173-81.
2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506.
3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48.

Product Images

<p>Chemical structure of DAPT (SIH-378), a γ-secretase inhibitor. CAS #: 208255-80-5. Molecular Formula: C23H26F2N2O4. Molecular Weight: 432.46 g/mol.</p>

Chemical structure of DAPT (SIH-378), a γ-secretase inhibitor. CAS #: 208255-80-5. Molecular Formula: C23H26F2N2O4. Molecular Weight: 432.46 g/mol.

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