Discovery through Partnership | Excellence through Quality
| Product Name | Dimethyloxaloylglycine (DMOG) |
| Description |
Prolyl-4-hydroxylase inhibitor |
| Purity | >99% |
| CAS No. | 89464-63-1 |
| Molecular Formula | C6H9NO5 |
| Molecular Weight | 175.1 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml) or dimethyl formamide, or PBS pH7.2 (10 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | C(C(=O)OC)NC(C(=O)OC)=O |
| InChI | InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9) |
| InChIKey | BNJOZDZCRHCODO-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes Hazard Statements: H302 - Harmful if swallowed |
| Cite This Product | Dimethyloxaloylglycine (DMOG) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-382) |
Biological Description
| Alternative Names | DMOG, N-(Methoxyoxoacetyl)-glycine methyl ester |
| Research Areas | Cell Signaling |
| PubChem ID | 560326 |
| Scientific Background | DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic. |
| References |
1. Grozinger C.M., et al. (2001) J. Biol. Chem. 276(42): 38837-43. 2. Mai A., et al. (2005) J. Med. Chem. 48(24): 7789-95. 3. Kahyo T., et al. (2008) J. Pharmacol. Sci. 108(3): 364-71. 4. Jung-Hynes B., et al. (2009) J. Biol. Chem. 284(6): 3823-32. |
Product Images
Chemical structure of Dimethyloxaloylglycine (DMOG) (SIH-382), a Prolyl-4-hydroxylase inhibitor. CAS #: 89464-63-1. Molecular Formula: C6H9NO5. Molecular Weight: 175.1 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.