Eicosanoyl-5-hydroxytyptamide

A neuroprotective natural product found in coffee

Catalog No. SIH-615

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CAS No. N/A
Molecular Formula C30H50N2O2
SKU: SIH-615 Categories: ,

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SIH-615-Eicosanoyl-5-hydroxytyptamide-Chemical-Structure.png
Product Name Eicosanoyl-5-hydroxytyptamide
Description

A neuroprotective natural product found in coffee

Purity >98% (TLC); NMR (Conforms)
CAS No. N/A
Molecular Formula C30H50N2O2
Molecular Weight 470.7
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (30 mg/ml); or ethanol (20 mg/ml, warm)
Source Synthetic
Appearance Beige powder
Safety Phrases Classification: Caution- Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product Eicosanoyl-5-hydroxytyptamide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-615)

Biological Description

Alternative Names Eicosanoyl serotonin; Eicosanoyl-5-hydroxytryptamide; EHT
Research Areas Alzheimer's Disease, Neurodegeneration, Neuroscience, Synuclein, Tangles & Tau
Scientific Background A natural product found in coffee which synergizes with caffeine in protecting the brain in models of alpha-synucleinopathy (1). It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated alpha-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents ABeta-induced impairments in mouse models of Alzheimer’s disease (2,3).
References 1. Yan R., et al. (2018) Proc. Natl. Acad. Sci. USA . 115:E12053
2. Asam K., et al. (2017) PLoS One. 12:e0189413
3. Basurto-Islas G., et al. (2014) Neurobiol. Aging. 35:2701

Product Images

<p>Chemical structure of Eicosanoyl-5-hydroxytyptamide (SIH-615), a A neuroprotective natural product found in coffee. CAS #: N/A. Molecular Formula: C30H50N2O2  . Molecular Weight: 470.7 g/mol.</p>

Chemical structure of Eicosanoyl-5-hydroxytyptamide (SIH-615), a A neuroprotective natural product found in coffee. CAS #: N/A. Molecular Formula: C30H50N2O2 . Molecular Weight: 470.7 g/mol.

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