Entacapone

COMT inhibitor

Catalog No. SIH-578

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CAS No. 130929-57-6
Molecular Formula C14H15N3O5
SKU: SIH-578 Categories: ,

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SIH-578-Entacapone-Chemical-Structure.png
Product Name Entacapone
Description

COMT inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 130929-57-6
Molecular Formula C14H15N3O5
Molecular Weight 305.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (30 mg/ml); or ethanol (3 mg/ml)
Source Synthetic
Appearance Yellow powder
SMILES OC1=CC(/C=C(C#N)/C(N(CC)CC)=O)=CC([N+]([O-])=O)=C1O
InChI InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+
InChIKey JRURYQJSLYLRLN-BJMVGYQFSA-N
Safety Phrases Classification: Not a hazardous substance or mixture.
Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Entacapone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-578)

Biological Description

Alternative Names (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Research Areas Cell Signaling, Neurodegeneration, Neuroscience, Neurotransmission, Parkinson's Disease, Synuclein
PubChem ID 5281081
Scientific Background Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). It is used in the therapy of Parkinson's Disease as adjunctive therapy in conjuction with levodopa and carbidopa. It inhibits alpha synuclein and beta-amyloid oligomerization and fibrillogenesis.
References 1. Di Giovanni S., et al. (2010) J Biol Chem. 285 (20): 14941-14954.

Product Images

<p>Chemical structure of Entacapone (SIH-578), a COMT inhibitor. CAS #: 130929-57-6. Molecular Formula: C14H15N3O5. Molecular Weight: 305.29 g/mol.</p>

Chemical structure of Entacapone (SIH-578), a COMT inhibitor. CAS #: 130929-57-6. Molecular Formula: C14H15N3O5. Molecular Weight: 305.29 g/mol.

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