Fasudil

ROCK inhibitor

Catalog No. SIH-371

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CAS No. 103745-39-7
Molecular Formula C14H17N3O2S•HCl
SKU: SIH-371 Categories: ,

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SIH-371_Fasudil_Chemical_Structure.png
Product Name Fasudil
Description

ROCK inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 103745-39-7
Molecular Formula C14H17N3O2S•HCl
Molecular Weight 327.83
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (75 mg/ml) or water (100 mg/ml)
Source Synthetic
Appearance Powder
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
InChI InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2
InChIKey NGOGFTYYXHNFQH-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Fasudil (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-371)

Biological Description

Alternative Names 1-(5-Isoquinolinylsulfonyl) homopiperazine hydrochloride; 5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline
Research Areas Cell Signaling, Neurodegeneration, Neuroscience, Parkinson's Disease, Synuclein
PubChem ID 3547
Scientific Background Fasudil is a ROCK2 inhibitor with some action on PRK2 and MSK1 (IC50 values are 1.9 µM, 4 µM and 5 µM respectively). It is also shown to inhibit RSK1, RSK2, PKA, AMPK and PKd1. It is also a calcium channel antagonist and vasodilator.
References 1. Shirotani M., et al. (1991) J. Pharmacol. Exp. Ther. 259(2): 738-744.
2. Arai M., Nozawa R., et al. (1993) Biochem. Pharmacol. 46(8): 1487-1490.
3. Satoh S., et al. (1996) Br. J. Pharmacol. 118(7): 1592-1606.
4. Sward K., et al. (2000) J. Physiol. 522: 33-49.

Product Images

<p>Chemical structure of Fasudil (SIH-371), a ROCK inhibitor. CAS #: 103745-39-7. Molecular Formula: C14H17 N3O2S•HCl. Molecular Weight: 327.83 g/mol.</p>

Chemical structure of Fasudil (SIH-371), a ROCK inhibitor. CAS #: 103745-39-7. Molecular Formula: C14H17 N3O2S•HCl. Molecular Weight: 327.83 g/mol.

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