Product Name | Fasudil |
Description |
ROCK inhibitor |
Purity | >98% (TLC); NMR (Conforms) |
CAS No. | 103745-39-7 |
Molecular Formula | C14H17N3O2S•HCl |
Molecular Weight | 327.83 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Inhibitor |
Solubility | May be dissolved in DMSO (75 mg/ml) or water (100 mg/ml) |
Source | Synthetic |
Appearance | Powder |
SMILES | C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3 |
InChI | InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2 |
InChIKey | NGOGFTYYXHNFQH-UHFFFAOYSA-N |
Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
Cite This Product | Fasudil (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-371) |
Alternative Names | 1-(5-Isoquinolinylsulfonyl) homopiperazine hydrochloride; 5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline |
Research Areas | Cell Signaling, Neurodegeneration, Neuroscience, Parkinson's Disease, Synuclein |
PubChem ID | 3547 |
Scientific Background | Fasudil is a ROCK2 inhibitor with some action on PRK2 and MSK1 (IC50 values are 1.9 µM, 4 µM and 5 µM respectively). It is also shown to inhibit RSK1, RSK2, PKA, AMPK and PKd1. It is also a calcium channel antagonist and vasodilator. |
References |
1. Shirotani M., et al. (1991) J. Pharmacol. Exp. Ther. 259(2): 738-744. 2. Arai M., Nozawa R., et al. (1993) Biochem. Pharmacol. 46(8): 1487-1490. 3. Satoh S., et al. (1996) Br. J. Pharmacol. 118(7): 1592-1606. 4. Sward K., et al. (2000) J. Physiol. 522: 33-49. |
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