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| Product Name | Galanthamine HBr |
| Description |
Acetylcholinesterase inhibitor |
| Purity | >97% (HPLC); NMR (Conforms) |
| CAS No. | 1953-04-4 |
| Molecular Formula | C17H22BrNO3 |
| Molecular Weight | 368.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Blue Ice or 4ºC |
| Product Type | Inhibitor |
| Solubility | Soluble in water (12 mg/ml) or in DMSO (10 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | [Br-].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24.[H+] |
| InChI | 1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1 |
| InChIKey | QORVDGQLPPAFRS-XPSHAMGMSA-N |
| Safety Phrases |
Classification: D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion Hazard statement(s): H301 Toxic if swallowed. Precautionary statement(s): P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. |
| Cite This Product | Galanthamine HBr (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-530) |
Biological Description
| Alternative Names | Galantamine hydrobromide, Galantamine HBr, Galanthamine hydrobromide, Galanthamine, Galanthamine hydrogen bromide, SPECTRUM1501202, 1,2,3,4,6,7,7a,11c-Octahydro-9-methoxy-2-methyl-benzofuro(4,3,2-efg)(2)benzazocin-6-ol HBr, LS-185021, Galanthamine, Nivalin, Reminyl, Jilkon hydrobromide, Lycoremine hydrobromide |
| Research Areas | Alzheimer's Disease, Apoptosis, Cancer, Neurodegeneration, Neuroscience |
| PubChem ID | 121587 |
| Scientific Background | Galantamine hydrobromide is a long-acting, active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. It prevents β-amyloid-induced apoptosis in SH-SY5Y. Long-term administration in a mouse model of Alzheimer's disease reduces amyloid precursor protein deposition and neurodegeneration in these mice. |
Product Images
Chemical structure of Galanthamine HBr (SIH-530), a Acetylcholinesterase inhibitor. CAS #: 1953-04-4. Molecular Formula: C17H22BrNO3. Molecular Weight: 368.3 g/mol.
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