Garcinol

Name: Garcinol
SKU: SIH-355
Availability: InStock

HAT inhibitor

Catalog No. SIH-355

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CAS No.	78824-30-3
Molecular Formula	C38H50O6

SKU: SIH-355 Categories: Inhibitor, Small Molecules

Product Name	Garcinol
Description	HAT inhibitor
Purity	>98% (TLC); NMR (Conforms)
CAS No.	78824-30-3
Molecular Formula	C₃₈H₅₀O₆
Molecular Weight	602.8
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
Source	Synthetic
Appearance	Yellow solid
SMILES	CC(=CC[C@@H]1C[C@@]2(C(=C(C(=O)[C@@](C2=O)(C1(C)C)CC=C(C)C)C(=O)C3=CC(=C(C=C3)O)O)O)C[C@H](CC=C(C)C)C(=C)C)C
InChI	InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21
InChIKey	DTTONLKLWRTCAB-UDFURZHRSA-N
Safety Phrases	Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Cite This Product	Garcinol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-355)

Alternative Names	Camboginol, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-bicyclo[3.3.1]non-3-ene-2,9-dione
Research Areas	Cell Signaling
PubChem ID	5490884
Scientific Background	Potent inhibitor of histone acetyl transferases p300 (IC50=7 mM) and pCAF (IC50=5 mM) (1). Induces apoptosis in various cell lines (2). Promotes expansion of human hematopoietic stem cells(3). Cell permeable.
References	1. Balasubramanyam K., et al., (2004) J. Biol. Chem. 279: 33716. 2. Parasramka M.A., et al. (2011) Nutr. Cancer. 63: 456. 3. Nishino T., et al. (2011) Nutr. PLoS One 6: e24298.

Chemical structure of Garcinol (SIH-355), a HAT inhibitor. CAS #: 78824-30-3. Molecular Formula: C38H50O6. Molecular Weight: 602.8 g/mol.

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