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| Product Name | GW2580 |
| Description |
cFMS kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 870483-87-7 |
| Molecular Formula | C20H22N4O3 |
| Molecular Weight | 366.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO: 10 mg/ml, clear (warmed) |
| Source | Synthetic |
| Appearance | White to beige solid |
| SMILES | COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC |
| InChI | InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) |
| InChIKey | MYQAUKPBNJWPIE-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 4), H302 Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh a ir and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well - ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | GW2580 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-449) |
Biological Description
| Alternative Names | 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-Pyrimidinediamine, 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine, GW 2580, GW-2580 |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 11617559 |
| Scientific Background | GW2580 is a potent and selective, ATP-competitive inhibitor of cFMS kinase. It also inhibits macrophage-colony stimulating factor receptor, M-CSF/ CSF-1. cFMS is a type III receptor tyrosine kinase that binds to M-CSF or CSF-1. Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states. |
| References |
1. Conway J.G., et al. (2008) J. Pharm. Exp. Ther. 326(1): 41–50. 2. Conway J.G., et al. (2005) Pro. Nat. Acad. Sci. USA. 102(44): 16078–16083. |
Product Images
Chemical structure of GW2580 (SIH-449), a cFMS kinase inhibitor. CAS #: 870483-87-7. Molecular Formula: C20H22N4O3. Molecular Weight: 366.4 g/mol.
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