HC-030031

TRPA1 blocker

Catalog No. SIH-303

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CAS No. 349085-38-7
Molecular Formula C18H21N5O3
SKU: SIH-303 Categories: ,

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SIH-303_HC-030031_Chemical_Structure.png
Product Name HC-030031
Description

TRPA1 blocker

Purity >98%
CAS No. 349085-38-7
Molecular Formula C18H21N5O3
Molecular Weight 355.39
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance White solid
SMILES CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C
InChI InChI=1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)
InChIKey HEQDZPHDVAOBLN-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
Cite This Product HC-030031 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-303)

Biological Description

Alternative Names 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
Research Areas Ion Channels, Neuroscience
PubChem ID 1150897
Scientific Background Selective TRPA1 channel blocker that antagonizes AITC-and formalin-evoked calcium influx. Doe not block currents mediated by TRPV1, V3, V4, hERG or Nav1.2 channels (1-2).
References 1. McNamara C.R., et al. (2007) Proc Natl Acad Sci USA. 104(33): 13525-13530.
2. Taylor-Clark T.E., et al. (2008) Mol Pharmacol. 73(2): 274-281.

Product Images

<p>Chemical structure of HC-030031 (SIH-303), a TRPA1 blocker. CAS #: 349085-38-7. Molecular Formula: C18H21N5O3. Molecular Weight: 355.39 g/mol.</p>

Chemical structure of HC-030031 (SIH-303), a TRPA1 blocker. CAS #: 349085-38-7. Molecular Formula: C18H21N5O3. Molecular Weight: 355.39 g/mol.

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