Huperzine A

ACH inhibitor

Catalog No. SIH-365

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CAS No. 102518-79-6
Molecular Formula C15H18N2O
SKU: SIH-365 Categories: ,

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SIH-365_Huperzine_A_Chemical_Structure.png
Product Name Huperzine A
Description

ACH inhibitor

Purity >95% (HPLC); NMR (conforms)
CAS No. 102518-79-6
Molecular Formula C15H18N2O
Molecular Weight 242.32
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO, methanol or ethanol.
Source Synthetic
Appearance Off-White solid
SMILES C/C=C/1[C@@H]2CC3=C([C@]1(CC(=C2)C)N)C=CC(=O)N3
InChI InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10?,15-/m1/s1
InChIKey ZRJBHWIHUMBLCN-JYXJEATCSA-N
Safety Phrases Classification: Toxic
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H301+ H311 +H331 – Toxic if swallowed, in contact with skin or inhaled
H315 - Causes skin irritation.
H319 - Causes serious eye irritation.
H335 - May cause respiratory irritation.
Precautionary Phrases:
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 - Wear protective gloves/protective clothing.
P301+ P310 – IF SWALLOWED: Immediately call POISON CENTER or doctor/physician.
P305+ P351+ P338 – IF IN EYES: rinse cautiously with water for several minutes. If wearing contact lenses remove them and continue to rinse.
P311 – call a POISON CENTER or doctor/physician
Cite This Product Huperzine A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-365)

Biological Description

Alternative Names (1R,9S,13E)- 1-Amino- 13-ethylidene- 11-methyl- 6-azatricyclo[7.3.1.02,7] trideca- 2(7),3,10- trien- 5-one
Research Areas Glutamate Receptors, Ion Channels, Neuroscience, Neurotransmitter Receptors, NMDA Receptors
PubChem ID 44461111
Scientific Background Huperzine A is an acetylcholinesterase inhibitor. It is known for enhancing learning and memory by protecting a neurotransmitter molecule in the brain. Huperzine is also a NMDA glutamate receptor antagonist (1-2). The effects on the treatment of Alzheimer’s disease is under studies (1-3). Recent studies of Huperzine A highlight the potential therapeutic use for dementia by slowing down the neuronal cell death caused by glutamate (4).
References 1. Bai Dl., Tang Xc., He YC., Curr MedChem. (2000) 7(3): 355-74.
2. Tang L., Wang r., Tang x., (2005) Acta Acta Pharmacologica 26(6): 673-678.
3. Ved Hs,. Koenig ml., Dave JR., Doctor BP.(1997) Neurorport. 8(4): 963-8.
4. Li WM., Kan KK., Carlier PR., Pang YP., Han YF. YF., (2007) Curr Alzheimer Res. 4: 386-396.

Product Images

<p>Chemical structure of Huperzine A (SIH-365), a ACH inhibitor. CAS #: 102518-79-6. Molecular Formula: C15H18N2O. Molecular Weight: 242.32 g/mol.</p>

Chemical structure of Huperzine A (SIH-365), a ACH inhibitor. CAS #: 102518-79-6. Molecular Formula: C15H18N2O. Molecular Weight: 242.32 g/mol.

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