IU1

Name: IU1
SKU: SIH-329
Availability: InStock

Usp-14 inhibitor

Catalog No. SIH-329

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CAS No.	314245-33-5
Molecular Formula	C18H21FN2O

SKU: SIH-329 Categories: Inhibitor, Small Molecules

Product Name	IU1
Description	Usp-14 inhibitor
Purity	>98%
CAS No.	314245-33-5
Molecular Formula	C₁₈H₂₁FN₂O
Molecular Weight	300.4
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 30 mg/ml DMSO, 15 mg/ml Ethanol
Source	Synthetic
Appearance	Beige Solid
SMILES	CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
InChI	InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
InChIKey	JUWDSDKJBMFLHE-UHFFFAOYSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H303 – May be harmful if swallowed H318 – Causes serious eye damage Precautionary Statements: P280 – Wear protective gloves/ eye protection/ face protection P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses.
Cite This Product	IU1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-329)

Alternative Names	1-[1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-pyrrolidin-1-yl-ethanone
Research Areas	Apoptosis, Cancer
PubChem ID	675434
Scientific Background	Selective inhibitor of Usp14 (IC50<4 M). Enhances proteasome activity and substrate proteolysis. Cell permeable.
References	1. Lee B.H., et al. (2010) Nature 467: 1179. 2. Lee B.H., et al. (2010) Mol. Cell. Proteomics 10: R1100003871.

Chemical structure of IU1 (SIH-329), a Usp-14 inhibitor. CAS #: 314245-33-5. Molecular Formula: C18H21FN2O . Molecular Weight: 300.4 g/mol.

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