KB-R7943 mesylate

TRPC channel blocker

Catalog No. SIH-312

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CAS No. 182004-65-5
Molecular Formula C16H17N3O3S•CH3SO3H
SKU: SIH-312 Categories: ,

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SIH-312_KB-R7943_mesylate_Chemical_Structure.png
Product Name KB-R7943 mesylate
Description

TRPC channel blocker

Purity >98% (TLC); NMR (Conforms)
CAS No. 182004-65-5
Molecular Formula C16H17N3O3S•CH3SO3H
Molecular Weight 427.29
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance White Solid
SMILES CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-]
InChI InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChIKey WGIKEBHIKKWJLG-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product KB-R7943 mesylate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-312)

Biological Description

Alternative Names 2-{4-[(4-Nitrobenzyl)oxy]phenyl}ethyl carbamimidothioate methanesulfonate (1:1)
Research Areas Ion Channels, Neuroscience
PubChem ID 9823846
Scientific Background KN-R9743 mesylate is a potent selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger. It also inhibits the mitochondrial Ca2+ uniporter. It does not affect Na+ dependent transport systems or ionotropic glutamate receptors.
References 1. Hoyt K.R., Arden S.R., Aizenman E. and Reynolds I.J. (1998) Mol Pharmacol. 53(4): 742-749.
2. Schroder U.H., Breder J, Sabelhaus C.F., Reymann K.G. (1999) Neuropharm. 38(2): 319-321.
3. Watano T., Harada Y., Harada K., Nishimura N. (1999) Br J Pharmacol. 127(8): 1846-1850.

Product Images

<p>Chemical structure of KB-R7943 mesylate (SIH-312), a TRPC channel blocker. CAS #: 182004-65-5. Molecular Formula: C16H17N3O3S.CH3SO3H. Molecular Weight: 427.29 g/mol.</p>

Chemical structure of KB-R7943 mesylate (SIH-312), a TRPC channel blocker. CAS #: 182004-65-5. Molecular Formula: C16H17N3O3S.CH3SO3H. Molecular Weight: 427.29 g/mol.

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