KNK 437

Name: KNK 437
SKU: SIH-599
Availability: InStock

HSP70 Inhibitor

Catalog No. SIH-599

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CAS No.	218924-25-5
Molecular Formula	C13H11NO4

SKU: SIH-599 Categories: Inhibitor, Small Molecules

Product Name	KNK 437
Description	HSP70 Inhibitor
Purity	>98% (HPLC); NMR (conforms)
CAS No.	218924-25-5
Molecular Formula	C₁₃H₁₁NO₄
Molecular Weight	245.2
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	May be dissolved in DMSO (30 mg/ml)
Source	Synthetic
Appearance	Off-white powder
SMILES	C1CN(C(=O)C1=CC2=CC3=C(C=C2)OCO3)C=O
InChI	InChI=1S/C13H11NO4/c15-7-14-4-3-10(13(14)16)5-9-1-2-11-12(6-9)18-8-17-11/h1-2,5-7H,3-4,8H2/b10-5+
InChIKey	LZGGUFLRKIMBDQ-BJMVGYQFSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	KNK 437 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-599)

Alternative Names	3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
Research Areas	Cancer, Heat Shock
PubChem ID	46195007
Scientific Background	KNK 437 is an inhibitor of the acquisition of thermotolerance caused by the induction of HSPs, including HSP105, HSP70, and HSP40 in human colon carcinoma cells (1). It has also been tested in anti-tumor therapy of colorectal cancer (2).
References	1. Yokota S., Kitahara M., and Nagata K. (2000) Cancer Res. 60 (11): 2942-2948. 2. Yang S., et al. (2020) Oncogene. 39: 249-261.

Chemical structure of KNK 437 (SIH-599), a HSP70 Inhibitor. CAS #: 218924-25-5. Molecular Formula: C13H11NO4. Molecular Weight: 245.2 g/mol.

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