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| Product Name | LY364947 |
| Description |
ALK5 kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 396129-53-6 |
| Molecular Formula | C17H12N4 |
| Molecular Weight | 272.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | Yellow to brown solid |
| SMILES | C1=CC=C2C(=C1)C(=CC=N2)C3=CNN=C3C4=CC=CC=N4 |
| InChI | InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) |
| InChIKey | IBCXZJCWDGCXQT-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 3), H301 Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H410 Very toxic to aquatic life with long lasting effects. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P391 Collect spillage. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | LY364947 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-504) |
Biological Description
| Alternative Names | LY 364947, HTS 466284, ALK5 Inhibitor I, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline, HTS 466284, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 447966 |
| Scientific Background | LY364947 is a potent and selective inhibitor of TGF-β type-1 receptor kinase. Specifically, it inhibits TGF-β signaling and gene transcription. LY364947 is cell permeable and ATP-competitive. |
| References | 1. Vogt J., Traynor R., & Sapkota G.P. (2011) Cell. Signal. 23(11): 1831–1842. |
Product Images
Chemical structure of LY364947 (SIH-504), a ALK5 kinase inhibitor. CAS #: 396129-53-6. Molecular Formula: C17H12N4. Molecular Weight: 272.3 g/mol.
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