Mycophenolate mofetil

Inosine monophosphate dehydrogenase inhibitor

Catalog No. SIH-568

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CAS No. 128794-94-5
Molecular Formula C23H31NO7
SKU: SIH-568 Categories: ,

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SIH-568-Mycophenolate-mofetil-Chemical-Structure.png
Product Name Mycophenolate mofetil
Description

Inosine monophosphate dehydrogenase inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 128794-94-5
Molecular Formula C23H31NO7
Molecular Weight 433.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (40 mg/ml); or ethanol (4 mg/ml)
Source Synthetic
Appearance White powder
SMILES C/C(=CCc1c(c2c(COC2=O)c(C)c1OC)O)/CCC(=O)OCCN1CCOCC1
InChI InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+
InChIKey RTGDFNSFWBGLEC-SYZQJQIISA-N
Safety Phrases GHS Classifcation: GHS07 Acute toxicity (oral, dermal, inhalation), category 4, Skin irritation, category 2, Eye irritation, category 2, Skin sensitisation, category 1, Specific Target Organ Toxicity – Single exposure, category 3 AND GHSO9 Hazardous to the aquatic environment, Acute hazard, category1, Chronic hazard, categories 1,2 Hazard statement(s): H302-H400 Precautionary statement(s): P273
Cite This Product Mycophenolate mofetil (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-568)

Biological Description

Alternative Names 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester
Research Areas Adaptive Immunity, Astrocyte Markers, Autoimmune, B Cells, Cell Markers, Glial Markers, Immunology, Microglia Markers, Neuroscience
PubChem ID 5281078
Scientific Background Mycophenolate mofetil is an immunosuppressive agent useful in prevention of organ allograft rejection (1). It is metabolized to mycophenolic acid in vivo, which acts by inhibiting the biosynthesis of guanine nucleotides via inhibition of inosine 5’-monophosphate dehydrogenase, suppressing the production of proinflammatory cytokines, nitric oxide and LDH in macrophages (2,3). It also inhibits IL-2-dependent T cell proliferation (4), and microglial and astrocytic activation reducing cell death after neuronal injury (5). It also prevents neuroinflammation.
References 1. Allison A.C., and Eugui, E.M. (1996) Clin. Transplant. 10:77.
2. Jonsson C.A., et al., (2002) Cell. Immunol. 216:93.
3. Allison A.C., et al., (1993) Ann. NY Acad. Sci. 696:63.
4. Quemeneur J., et al., (2002) J. Immunol. 169:2747
5. Ebrahimi F., et al., (2012) J. Neuroinflammation 9:89.

Product Images

<p>Chemical structure of Mycophenolate mofetil (SIH-568), a Inosine monophosphate dehydrogenase inhibitor. CAS #: 128794-94-5. Molecular Formula: C23H31NO7. Molecular Weight: 433.5 g/mol.</p>

Chemical structure of Mycophenolate mofetil (SIH-568), a Inosine monophosphate dehydrogenase inhibitor. CAS #: 128794-94-5. Molecular Formula: C23H31NO7. Molecular Weight: 433.5 g/mol.

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