NLRP3

NLRP3 inflammasome activation inhibitor

Catalog No. SIH-604

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CAS No. 256373-96-3
Molecular Formula C20H23N2O5S ∙ Na
SKU: SIH-604 Categories: ,

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SIH-604-NLRP3-Chemical-Structure.png
Product Name NLRP3
Description

NLRP3 inflammasome activation inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 256373-96-3
Molecular Formula C20H23N2O5S ∙ Na
Molecular Weight 426.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in water (30 mg/ml): or DMSO (40 mg/ml)
Source Synthetic
Appearance White powder
SMILES COC1=CC=C(C=C1)CC(=O)NC2=CC(=CC=C2)O
InChI InChI=1S/C15H15NO3/c1-19-14-7-5-11(6-8-14)9-15(18)16-12-3-2-4-13(17)10-12/h2-8,10,17H,9H2,1H3,(H,16,18)
InChIKey OTXSEOHBMQFDBM-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Not a hazardous substance or mixture.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product NLRP3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-604)

Biological Description

Alternative Names N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt; CRID3; CP-456773 sodium salt
Research Areas Cancer, Cell Signaling, Growth Factors, Neuroscience, TNF
PubChem ID 1234617
Scientific Background NLRP3 (MCC950) was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-1(1). Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes(2). Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1β (IL-1β) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model)(3). Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome(4). A valuable new tool for exploring the pathophysiology of NLRP3.
References 1.,Laliberte R.E. et al. (2003) J. Biol. Chem. 278(19):16567-78.
2.,Coll R.C., et al. (2011) PLoS One. 6(12):e29539.
3.,Coll R.C., et al. (2015) Nat. Med. 21(3):248-255.
4.,Kaneko N., et al. (2015) J. Immunol. Methods. 426:76-81.

Product Images

<p>Chemical structure of NLRP3 (SIH-604), a NLRP3 inflammasome activation inhibitor. CAS #: 256373-96-3. Molecular Formula: C20H23N2O5S ∙ Na. Molecular Weight: 426.5 g/mol.</p>

Chemical structure of NLRP3 (SIH-604), a NLRP3 inflammasome activation inhibitor. CAS #: 256373-96-3. Molecular Formula: C20H23N2O5S ∙ Na. Molecular Weight: 426.5 g/mol.

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