Nutlin-3

Name: Nutlin-3
SKU: SIH-344
Availability: InStock

p53/mdm2 inhibitor

Catalog No. SIH-344

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CAS No.	548472-68-0
Molecular Formula	C30H30Cl2N4O4

SKU: SIH-344 Categories: Inhibitor, Small Molecules

Product Name	Nutlin-3
Description	p53/mdm2 inhibitor
Purity	>98%
CAS No.	548472-68-0
Molecular Formula	C₃₀H₃₀Cl₂N₄O₄
Molecular Weight	581.9
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 100 mM DMSO and Ethanol
Source	Synthetic
Appearance	Yellow solid
SMILES	CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
InChI	InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)
InChIKey	BDUHCSBCVGXTJM-UHFFFAOYSA-N
Safety Phrases	Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Cite This Product	Nutlin-3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-344)

Alternative Names	(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, p53/mdm2 Inhibitors
PubChem ID	216345
Scientific Background	MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
References	1. Vassilev et al (2004) Science 303: 844.

Chemical structure of Nutlin-3 (SIH-344), a p53/mdm2 inhibitor. CAS #: 548472-68-0. Molecular Formula: C30H30Cl2N4O4. Molecular Weight: 581.9 g/mol.

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