Oridonin

HSP70 inhibitor & NLRP inflammasome inhibitor

Catalog No. SIH-624

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CAS No. 28957-04-2
Molecular Formula C20H28O6
SKU: SIH-624 Categories: ,

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SIH-624-Oridonin-Chemical-Structure
Product Name Oridonin
Description

HSP70 inhibitor & NLRP inflammasome inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 28957-04-2
Molecular Formula C20H28O6
Molecular Weight 364.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (50 mg/ml); or Ethanol (10 mg/ml, warm)
Source Synthetic
Appearance White to off-white powder
SMILES CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C
InChI InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1
InChIKey SDHTXBWLVGWJFT-XKCURVIJSA-N
Safety Phrases Classification: Warning. Hazard Statements: H351. Precautionary Statements: P203, P280, P318, P405, and P501
Cite This Product Oridonin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-624)

Biological Description

Alternative Names 7a,20-Epoxy-1a,6b,7,14-tetrahydroxykaur-16-en-15-one; Isodonol
Research Areas Apoptosis, Cancer, Stem Cells
PubChem ID 5321010
Scientific Background A potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models (1). Inhibits vascular inflammation in vivo (2). Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling (3). Inhibits migration, invasion and adhesion of melanoma cells (4). Induces apoptosis in osteosarcoma cells by multiple pathways (5).
References 1. He H., et al. (2018) Nat. Commun. 9:2550.
2. Huang W., et al. (2018) Eur. J. Pharmacol. 826:133.
3. Sun B., et al. (2018) Oncotarget 9:23878.
4. Li CY., et al. (2018) Oncol. Lett. 15:1362.
5. Lu Y., et al. (2018) Cell Death Dis. 9:15.

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