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| Product Name | Oridonin |
| Description |
HSP70 inhibitor & NLRP inflammasome inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 28957-04-2 |
| Molecular Formula | C20H28O6 |
| Molecular Weight | 364.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (50 mg/ml); or Ethanol (10 mg/ml, warm) |
| Source | Synthetic |
| Appearance | White to off-white powder |
| SMILES | CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C |
| InChI | InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1 |
| InChIKey | SDHTXBWLVGWJFT-XKCURVIJSA-N |
| Safety Phrases | Classification: Warning. Hazard Statements: H351. Precautionary Statements: P203, P280, P318, P405, and P501 |
| Cite This Product | Oridonin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-624) |
Biological Description
| Alternative Names | 7a,20-Epoxy-1a,6b,7,14-tetrahydroxykaur-16-en-15-one; Isodonol |
| Research Areas | Apoptosis, Cancer, Stem Cells |
| PubChem ID | 5321010 |
| Scientific Background | A potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models (1). Inhibits vascular inflammation in vivo (2). Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling (3). Inhibits migration, invasion and adhesion of melanoma cells (4). Induces apoptosis in osteosarcoma cells by multiple pathways (5). |
| References |
1. He H., et al. (2018) Nat. Commun. 9:2550. 2. Huang W., et al. (2018) Eur. J. Pharmacol. 826:133. 3. Sun B., et al. (2018) Oncotarget 9:23878. 4. Li CY., et al. (2018) Oncol. Lett. 15:1362. 5. Lu Y., et al. (2018) Cell Death Dis. 9:15. |
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