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| Product Name | P32/98 |
| Description |
DPPIV/DPP4 inhibitor |
| Purity | >98% |
| CAS No. | 136259-20-6 |
| Molecular Formula | C9H18N2OS•0.5C4H4O4 |
| Molecular Weight | 260.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in water (20 mg/ml) or DMSO (25 mg/ml) |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CCC(C)C(C(=O)N1CCSC1)N.C(=CC(=O)O)C(=O)O |
| InChI | InChI=1S/C9H18N2OS.C4H4O4/c1-3-7(2)8(10)9(12)11-4-5-13-6-11;5-3(6)1-2-4(7)8/h7-8H,3-6,10H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ |
| InChIKey | ZSOPWZQRZHWYFY-WLHGVMLRSA-N |
| Safety Phrases |
Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes |
| Cite This Product | P32/98 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-385) |
Biological Description
| Alternative Names | 3-N-[((2S,3S)-2-Amino-3-methylpentanoyl]-1,3-thiazolidine. hemi-fumarate, (2S,3S)-2-Amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one fumarate |
| Research Areas | Cell Signaling |
| PubChem ID | 77519185 |
| Scientific Background | P32/98 (Ile-thiazolidide) is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV; DPPIV; CD26), with a Ki of 130 nM (1-3). Useful in diabetes research. Has been used in vivo (10mg/kg orally twice daily)(4-7) and in tissue culture (1-10 µM) (8). |
| References |
1. Schön E., et al. (1991) Biol. Chem. Hoppe Seyler. 372(5): 305-11. 2. Pederson R.A., et al. (1998) Diabetes. 47(8): 1253-8. 3. Lankas G.R., et al. (2005) Diabetes. 54(10): 2988-94. 4. Pospisilik J.A., et al. (2002) Diabetes. 51(4): 943-50. 5. Pospisilik J.A., et al. (2002) Diabetes. 51(9): 2677-83. 6. Pospisilik J.A., et al. (2003) Diabetes. 52(3): 741-50. 7. Meyer A., et al. (1993) J. Chromatogr. B. 796(2): 401-11. 8. Girardi A.C.C., et al. (2004) Am. J. Physiol. Cell. Physiol. 287(5): C1238-45. |
Product Images
Chemical structure of P32/98 (SIH-385), a DPPIV/DPP4 inhibitor. CAS #: 136259-20-6. Molecular Formula: C9H18N2OS . 0.5 C4H4O4. Molecular Weight: 260.4 g/mol.
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