Product Name | Pifithrin mu |
Description |
Hsp70 inhibitor |
Purity | >98% |
CAS No. | 64984-31-2 |
Molecular Formula | C8H7NO2S |
Molecular Weight | 181.2 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Inhibitor |
Solubility | Soluble in ethanol (110 mM) and in DMSO (110 mM) |
Source | Synthetic |
Appearance | White to off-white solid |
SMILES | C1=CC=C(C=C1)C#CS(=O)(=O)N |
InChI | InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11) |
InChIKey | ZZUZYEMRHCMVTB-UHFFFAOYSA-N |
Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Phrases: H302-H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338 |
Cite This Product | Pifithrin mu (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-325) |
Alternative Names | 2-Phenylethynesulfonamide, PFTµ |
Research Areas | Cancer, Heat Shock |
PubChem ID | 327653 |
Scientific Background | Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com. |
References | 1. Leu J.L., et al. (2009) Mol. Cell. 36: 15. |
StressMarq Biosciences :
Based on validation through cited publications.