PP1

Name: PP1
SKU: SIH-469
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Src kinase inhibitor

Catalog No. SIH-469

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CAS No.	172889-26-8
Molecular Formula	C16H19N5

SKU: SIH-469 Categories: Inhibitor, Small Molecules

Product Name	PP1
Description	Src kinase inhibitor
Purity	>98% (TLC)
CAS No.	172889-26-8
Molecular Formula	C₁₆H₁₉N₅
Molecular Weight	281.4
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol
Source	Synthetic
Appearance	Tan solid
SMILES	CC1=CC=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)(C)C
InChI	InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChIKey	ZVPDNRVYHLRXLX-UHFFFAOYSA-N
Safety Phrases	Classification: Acute toxicity, Oral (Category 3), H301 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product	PP1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-469)

Alternative Names	1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	1400
Scientific Background	PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. This has a range of effects and implications. Structural studies have revealed that PP1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases. PP1 displays > 8000-fold selectivity over ZAP-70 and JAK2.
References	1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701. 2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.

Chemical structure of PP1 (SIH-469), a Src family kinase inhibitor. CAS #: 172889-26-8. Molecular Formula: C16H19N5. Molecular Weight: 281.4 g/mol.

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